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2018
New directions in Parkinson’s disease diagnose and Alzheimer’s disease treatments
Prof Uri ASHERY, Sagol School of Neuroscience, School of Neurobiology Biochemistry & Biophysics, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Israel
Lundi 7 avril 2025 à 11h, Salle de réunion SPPIN.
Pt. I - Early Detection of Parkinson's Disease In a significant step forward in the Parkinson's research field, our lab is developing a new platform to allow diagnosis of PD. This is achieved by applying a combination of super- resolution microscopy and advanced analysis on skin biopsies from Parkinson’s disease (PD) patients and the detection and characterization of alpha-synuclein aggregates, the hallmark of PD. Using super-resolution microscopy, we also demonstrated how a specific drug impacts on alpha-synuclein aggregation. We will discuss the use of dSTORM super- resolution microscopy on different preparations to characterize alpha-synuclein aggregates and the future plan to implement these discoveries, in a minimally invasive manner, among family members of Parkinson's disease patients. Part II - Hyperbaric oxygen therapy for mitigating Alzheimer's symptoms Our lab investigates the mitigating effects of Hyperbaric oxygen treatment (HBOT), a medical administration of 100% oxygen at environmental pressure greater than 1 Atmosphere absolute, on different Alzheimer's disease (AD) mouse models. We have demonstrated that HBOT ameliorates AD-related pathologies including a reduction in neuroinflammation, improvement in vascular dysfunction, reduced hypoxia and beta-amyloid plaques and improvement in behavioral tasks. Hence, HBOT can renew brain tissue, thereby improving patients' neurological and cognitive state. We will discuss recent findings and the effects of HBOT on mitochondrial function and on female versus male mice.
The winding road of acute stress: Molecules, Circuits and Behavior
Dr. Johannes Bohacek, ETH Zurich
Jeudi 13 février 2025 à 10h, Salle de conférence.
In this talk, I will chronicle the 8-year journey of my lab, illustrating how I became interested in studying the molecular mechanisms underlying the acute stress response and how this interest has evolved into a comprehensive research program. I will begin with a broad introduction to the importance of understanding the acute stress response from a health perspective. Then, I will share insights from our extensive multiomic profiling of the hippocampus, which has led us to explore the role of the locus coeruleus noradrenergic system in depth. Additionally, I will discuss our complex analysis of rodent behavior using the latest machine learning tools. While I will only touch on the surface of these topics, I will also provide insights into career development and the lessons learned from my journey, spanning from postdoc to junior group leader and eventually tenured professor.